The Maryland Genetics of Interstitial Cystitis Study (MaGIC) collected information on several hundred families with two or more blood relatives with interstitial cystitis (IC) to investigate the genetic basis of the condition. The study sought to find genetic variants that are more prevalent in family members who have interstitial cystitis than in those who do not have the disease. Participants who had IC and at least one blood relative with the condition were enrolled. Information was collected via interview by phone, mail, or website.

The primary objective of the study was to identify genetic variants associated with IC, with the aim using the genetic information to advance understanding of the cause of the disease.

The study enrolled participants of 13 years of age or older who had IC or PBS; had at least one relative with IC, PBS, or similar urinary symptoms; were available for an interview by phone, mail, or website; and lived in the US or Canada.

Subjects meeting the above criteria who had Parkinson’s disease, Multiple Sclerosis, Spina bifida, or another neurologic disease that preceded interstitial cystitis symptoms were excluded.

Pedigree files based on tracking of IC and related conditions were generated.